Rivers completed 22-of-26 passes en route to 285 yards for the Chargers (4-3), who dominated the time of possession en route to their third victory in four games.
Ryan Mathews sparked San Diego's ground game, piling up 110 yards with a score on 21 carries, while Eddie Royal paced the receivers with four grabs for 69 yards and a touchdown.
The hapless Jaguars (0-7) couldn't get a touchdown out of backup signal-caller Chad Henne, who made good on 23-of-36 passes for 318 yards and an interception.
Mike Brown made five catches for 120 yards for Jacksonville.
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