Lynch finished with 77 rushing yards on 21 carries and made four catches for 78 more as the Seahawks (5-1) ran their home unbeaten streak to 11 games.
Wilson, meanwhile, passed for 257 yards on 23-of-31 efficiency and also picked up 61 rushing yards.
The Titans (3-3) fell for the second straight week under backup quarterback Ryan Fitzpatrick, who completed 17-of-29 pass attempts for 171 yards and a pair of interceptions. He also ran for 33 yards.
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