Locker made good on 18-for-24 passes for 149 yards in the triumph, but was knocked out the game after taking a hard hit from New York's Muhammad Wilkerson early in the third quarter.
The Tennessee signal-caller was taken off the field on a cart.
Geno Smith passed for 289 yards with a touchdown but surrendered two interceptions and lost a pair of fumbles for the Jets (2-2).
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