Sabathia, 33, suffered the injury during his start Friday, in which he picked up the win in a 5-1 Yankees victory over San Francisco. Sabathia limited the Giants to seven hits and the one run over seven innings.
On Monday the Yankees announced the Sabathia had a Grade 2 strain of the left hamstring. Team officials said such an injury usually takes eight weeks to heal. That ends Sabathia's season even if the Yankees make the playoffs. He was scheduled to make one more start before the end of the regular season.
Sabathia ends 2013 with a 14-13 record and 4.78 earned run average. He started 32 games and pitched 211 innings.
Over his 13-year major-league career, Sabathia is 205-115 with a 3.60 ERA, having given up 2,585 hits over 2,775.1 innings covering 415 appearances -- all starts.
He played for the Cleveland Indians from 2001-08 before joining the Milwaukee Brewers for part of the 2008 season and then the Yankees in 2009. He is a six-time all-star and won the American League Cy Young Award in 2007.