David Ortiz contributed a bases-empty shot and Ryan Lavarnway added an RBI as the Red Sox took the rubber match of a three-game series.
Felix Doubront (11-6) allowed two runs on four hits over seven solid innings to notch the victory, and Koji Uehara secured it with his 21st save.
Blue Jays starter R.A. Dickey (13-13) was touched for five runs on six hits over eight full innings, striking out 11.
Kevin Pillar homered and knocked in both runs for Toronto.
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