Vettel surrendered the lead only once during a pit stop, otherwise breezing to his sixth win of the season. The Red Bull driver finished 5.4 seconds ahead of Ferrari's Fernando Alonso.
Germany's Vettel, who won the Italian event for the third time, increased his 2013 points total to 222 -- 53 more than Alonso with seven races remaining.
It was his 32nd career victory, putting him into a tie with Alonso for fourth on F1's all-time race winners list.
Alonso recorded his fourth consecutive podium appearance at the Italian Grand Prix.