Smith went 21-of-34 through the air for 173 yards and Jamaal Charles ran for 77 yards on 16 carries as Kansas City (1-0) corralled a win in a game that also featured the first appearance for new Chiefs head Coach Andy Reid.
Reid replaced Romeo Crennel, who was fired after Kansas City went 2-14 last season -- tied with the Jaguars for worst in the NFL.
Jacksonville's Blaine Gabbert managed to complete just 16-of-35 passes for 121 yards with a pair of interceptions before leaving the game in the fourth quarter with an apparent arm injury.
Maurice Jones-Drew picked up 45 yards on 15 carries for the Jaguars (0-1), who fell in the debut of their new head coach, Gus Bradley, who replaced the fired Mike Mularkey.
Easer Egg Roll brings thousands to White House
Turkey considering to use pistachios to heat country’s first eco-city