Romine's blow came after Mark Reynolds' run-scoring single ignited an eight-run Yankees explosion, during which they sent 13 men to the plate and banged out seven hits.
The Yanks, who came into the contest 3 1/2 games out of an American League wild card spot, won the first of a three-game series.
White Sox starter Jose Quintana (7-5) was saddled with the loss after yielding one run in the first inning preceding the delay, while reliever Dylan Axelrod surrendered all eight New York runs in the fourth.
Paul Konerko homered for Chicago.
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