That brought up Moss, who sliced an 0-1 pitch from Justin Verlander over the left-center field fence amid a heavy rain for a decisive two-run blast.
Seth Smith added a solo shot and Lowrie drove in a pair of runs for Oakland, which opened up a three-game lead over Cleveland for an American League wild card spot and grabbed a second win in two games against the Tigers.
Tommy Milone (10-9) needed to pitch only five innings to get the victory, yielding three runs (two earned) on three hits. He walked three and struck out three.
Verlander (12-10) had a rough outing, surrendering five runs (three earned) on four hits over five innings.
Prince Fielder drove in two runs for AL Central-leading Detroit.
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