Luck gained 20 yards on four rushes. Reggie Wayne caught seven passes for 79 yards and Kerwynn Williams led all rushers with 37 yards on nine carries.
Brandon Weeden was 12-of-25 passing for 105 yards and Jason Campbell was 8-for-14 for 112 yards for the Browns, who failed to score and managed just 104 yards total offense in the first half.
Trent Richardson carried the ball seven times for 31 yards for Cleveland.
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