Weaver (8-7) allowed only three hits, didn't issue a walk and fanned eight while tossing 68-of-102 pitches for strikes.
Kole Calhoun bashed a two-run homer, Chris Nelson added a two-run triple and Mark Trumbo went 2-for-5 with an RBI for the Angels, who completed a three-game sweep.
Seattle's Aaron Harang (5-11) was roughed up for seven runs on nine hits over 5 2/3 innings.
Dustin Ackley went 2-for-3 with a homer for the Mariners.
Notable deaths of 2014 [PHOTOS]
UPI Sports Results for September 19, 2014