Weaver (8-7) allowed only three hits, didn't issue a walk and fanned eight while tossing 68-of-102 pitches for strikes.
Kole Calhoun bashed a two-run homer, Chris Nelson added a two-run triple and Mark Trumbo went 2-for-5 with an RBI for the Angels, who completed a three-game sweep.
Seattle's Aaron Harang (5-11) was roughed up for seven runs on nine hits over 5 2/3 innings.
Dustin Ackley went 2-for-3 with a homer for the Mariners.
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