Wilson completed 8-of-12 passes and led Seattle to a score on its first possession, finding Jermaine Kearse on a 12-yard TD pass.
Kearse also contributed a 107-yard kickoff return for a touchdown while Brandon Browner returned a fumble 106 yards for another score for the Seahawks.
Peyton Manning led the Broncos with 163 passing yards on 11-of-16 efficiency.
Denver's receiving corps was paced by Demaryius Thomas, who made three grabs for 52 yards.
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Ron Burgundy interviews Peyton Manning on SportsCenter