The Twins came back from a three-run deficit in the late innings to drive the White Sox deeper into the cellar of the American League Central. Chicago's 74 losses are the second most in the majors ahead of only Houston.
Trevor Plouffe, who began the Minnesota comeback with a fifth-inning homer, singled to open the ninth. He moved to second on a passed ball and Chris Colabello drew a walk.
Plouffe was erased at third on a fielder's choice grounder by Clete Thomas, after which Bernier came on to run for Colabello at second. Herrmann came through with his single to right to bring home Bernier.
Jared Burton (2-6) worked the top of the ninth to get the win.