That brought up Choo, who lined a solid hit to right field for a decisive two-run single.
Brandon Phillips went 3-for-6 with an RBI for Cincinnati, which improved to 12-3 against the Cubs this season.
J.J. Hoover (3-5) was credited with the win after 2 1/3 shutout relief innings and Aroldis Chapman fired a 1-2-3 bottom of the 11th for his 29th save as the Reds reeled off a sixth victory in seven games.
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