The Cardinals came up with 14 hits to win their second straight on the heels of a seven-game losing streak.
St. Louis scored four times in the first and built a 12-0 lead through five innings.
Freese had a three-run double in the first to ignite the offense and added a bases-loaded walk during a four-run fourth.
Jay singled in a run during the first and had a two-run double in the fourth.
Shelby Miller (11-7) was the beneficiary of the offensive surge and was relieved after throwing 97 pitches in five-plus innings. He gave up three runs on five hits and struck out eight.
St. Louis got to Bronson Arroyo (9-9) for seven runs on eight hits in just 3 2/3.