The pole-sitter Newman changed just two tires on his last pit stop with 26 laps left while Jimmie Johnson -- who led for 73 of the 160 laps -- decided on a four-tire change during his final stop.
Johnson's 17.2-second stop cost him valuable track position, and Newman -- a South Bend, Ind., native -- took command down the stretch to best Johnson at the finish line by 2.7 seconds, claiming his initial victory of the season and first at Indianapolis.
It also marked Newman's 17th career Sprint Cup title.
Matt Kenseth rounded out the Top 5.
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