Encarnacion became the 26th player in American League history to hit two homers in the same inning. Adrian Beltre of Texas and Kendrys Morales of the Los Angeles Angels both did it last year.
Houston had a 6-4 lead heading into the bottom of the seventh, but 11 Blue Jays came to the plate in that inning. Three Houston pitchers combined to give up five hits, two walks and a hit batsman in the frame while the Astros were committing two errors.
Encarnacion led off the inning with a home run and when he came to bat again he connected on a grand slam for the final runs of the frame. Adam Lind also hit a solo home run in the inning.
Brett Cecil (4-1) recorded the final two outs in the top of the seventh to get the win. Paul Clemens (4-4) gave up the first six runs in the seventh inning to take the loss.