Colon (13-3) handed out just one walk and struck out five en route to his 12th career shutout and third of the year, matching a career high set in 2002.
The veteran right-hander has gone 10-1 with a 1.62 ERA in his last 13 starts for American League West-leading Oakland, which avoided a three-game sweep at the hands of the Angels.
Eric Sogard cracked a two-run homer and Brandon Moss went 3-for-4 with an RBI for the Athletics.
Los Angeles starter Jerome Williams (5-6) was touched for four runs (three earned) on eight hits in five innings.
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