Lincecum (5-9), a two-time Cy Young Award winner, issued four walks and struck out 13 in the effort, accomplishing the seventh no-hitter in Giants history and only the second on the road.
In the ninth, Lincecum fanned Chase Headley, then induced both Carlos Quentin Yonder Alonso to fly out to left-fielder Gregor Blanco. His pitch count was the second-highest for any no-hitter in major league history, trailing only Edwin Jackson's 149 pitches in a 2010 effort.
Right-fielder Hunter Pence kept the gem alive with a diving catch of an Alexi Amarista bullet to end the eighth inning.
Pence also led San Francisco at the plate, driving in five runs with a solo homer, a bases-clearing triple and a run-scoring groundout.
Brandon Belt smacked a two-run homer en route to three RBI for the Giants, who notched their third straight win over San Diego.
The Padres' Edinson Volquez (6-8) was roughed up for eight runs on nine hits over five innings as San Diego fell for the 14th time in 15 contests.
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