Jeter missed the first 91 games of the season while recovering from a broken ankle, an injury suffered in the playoffs last October.
He was activated off the 60-day disabled list and returned to the lineup as a designated hitter Thursday but left early with a leg problem. He was 1-for-4 with an RBI and run scored.
Yankees General Manager Brian Cashman on Friday said Jeter had a Grade 1 strain of his right quadriceps. He added that Jeter would be held out of the three games against the Minnesota Twins.
With the All-Star break early next week, the next game Jeter could play would be next Friday against the Red Sox in Boston.
Cashman said Jeter will be re-evaluated after the All-Star break and wouldn't rule out Jeter returning to the disabled list.