Toronto lost for the third time in four games after equaling the franchise record with 11 straight victories.
The Red Sox sent 11 men to the plate in the second and the first seven batters reached base.
Daniel Nava, Jarrod Saltalamacchia, Stephen Drew, Jose Eglesias and Jacob Ellsbury all drove in a run each before Pedroia hit his fifth home run of the year. That blast came after Shane Victorino had grounded into a double play to end the streak of Boston base runners.
Jon Lester (8-4) benefited from the outburst to get the win, giving up four runs on five hits in seven innings. He left the game with undisclosed injury after giving up two singles in the eighth.
Chien-Ming Wang (1-1) made his fourth start of the year for Toronto and was roughed up for seven runs on six hits in 1 2/3 innings.