Griffin (6-6) yielded just a fifth-inning single to Devin Mesoraco and a Xavier Paul double in the seventh in dominating the Reds.
The right-hander posted his first victory since May 25, a span of five starts, allowing a pair of walks and striking out seven in the 108-pitch gem.
Donaldson, who belted a two-run homer in Tuesday's 7-3 Oakland win in the first game of the interleague set, delivered a three-run blast Wednesday, highlighting a four-run outburst in the fourth inning.
Reds starter Homer Bailey (4-6) was reached for four runs on six hits over six full frames.
Cincinnati fell for the fifth time in six games.
Attkisson leaves CBS News, reportedly over network's 'liberal bias'
Astronomers offer more expansive view of universe