Martinez later added an RBI double while Omar Infante provided a two-run shot.
Jackson, Hunter and Andy Dirks each supplied three hits for the American League Central leaders, who rebounded from a 10-6 loss to the Red Sox in Friday's second contest of their four-game set.
Scherzer tamed the Bosox on two runs, yielding six hits without a walk while striking out six. He became the first Tigers pitcher since George Mullin in 1909 to begin the season with 11 consecutive victories.
Boston starter Allen Webster (0-2) was lit up for five runs on eight hits over 4 1/3 frames.
David Ortiz went 2-for-4 with a solo homer for the AL East-leading Red Sox.
Celebrity Families of 2014 [PHOTOS]