Lopez outlasted the second-seeded Frenchman in the Wimbledon grass-court tuneup 7-6 (7-2), 6-7 (5-7), 6-0.
Simon battled back from 1-4 to win the second set, but Lopez prevailed in a third set that was more competitive than the 6-0 score indicated. Lopez fired 16 aces versus four for Simon.
The match lasted nearly 3 hours in the blustery conditions in Eastbrooke.
Lopez, who won his first title since 2010, will face Simon again in the first round at Wimbledon, which begins Monday.
Notable deaths of 2014 [PHOTOS]