Boston built a 6-1 lead through four innings, surrendered a four-run fifth and then expanded its lead once more to win for the third time in five games.
Victorino hit a solo homer in the first, had a two-run single during a four-run fourth, contributed an RBI single in the sixth and brought home another run in the seventh on a fielder's choice grounder.
Boston scored in six different innings to bring Jon Lester a win despite a rough outing. Lester (7-4) gave up five runs on nine hits in 5 2/3.
The Red Sox shelled Doug Fister (6-5) for six runs on 11 hits in 3 1/3 innings. Six members of the Boston starting lineup had at least two hits
Miguel Cabrera went 4-for-4 and hit a three-run homer in the fifth that briefly brought the Tigers within one. Cabrera leads the majors with 74 RBI and his batting average has climbed to .366.