Williams, writing on her Facebook page, said she made the decision to break her string of 16 consecutive Wimbledon appearances due to a back injury.
"Unfortunately, I will not be able to participate in Wimbledon this year," she wrote. "I am extremely disappointed as I have always loved The Championships, but I need to take time to let my back heal."
The 33-year-old, who also has racked up three runner-up accolades at the All England Club, is along with her sister Serena Wimbledon's reigning doubles champion.
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