Colon (9-2) racked up a sixth win in six starts, limiting the Mariners to two runs on eight hits. The veteran right-hander didn't issue a walk and struck out three as the A's avoided a three-game sweep.
Reddick's run-scoring single in the fourth forged a 2-2 tie and his solo homer in the ninth capped the scoring as Oakland pounded out 17 hits.
Seattle's Hisashi Iwakuma (7-2) gave up four runs on eight hits in five innings.
Endy Chavez drove in both Mariners runs.
NBC reportedly holds celebs hostage to Jimmy Fallon's show
Millions of Getty images now available for free via embed tool