Erlin (1-0), called up from Class AAA Tacoma, pitched well in his initial start for the Padres, holding the Blue Jays to two runs on eight hits. The 22-year-old left-hander didn't issue a walk and struck out four.
Dale Thayer tossed 1 1/3 scoreless relief frames but Luke Gregerson, filling in at closer for the injured Huston Street, struggled in the ninth.
Colby Rasmus, Maicer Izturis and Melky Cabrera each delivered one-out singles to pull within a run, but Gregerson recovered for his first save when Emilio Bonifacio lined out and Jose Bautista grounded out to end the game.
Everth Cabrera went 3-for-4 with a pair of run-scoring singles and Kyle Blanks added an RBI as the Padres clinched their three-game set.
Toronto's Mark Buehrle (2-4) absorbed loss, surrendering four runs (three earned) on 10 hits over six frames.
Rasmus and Adam Lind each had two hits and an RBI for the Jays.
Notable deaths of 2014 [PHOTOS]