All of the fourth-inning runs came after two were out and gave the Indians their second straight win.
Scott Kazmir (3-2) was the beneficiary of the big inning and earned the win with a seven-inning effort. He worked around eight hits while striking out five.
All of Cleveland's runs were charged to Homer Bailey (3-4), who struck out two of the first four men he faced in the fourth before giving up six straight hits.
Two-out singles by Michael Brantley and Yan Gomes each delivered a run and Ryan Raburn next doubled home Brantley. Bourn followed with his double to left that scored two more, after which a base hit by Jason Kipnis and a double from Asdrubal Cabrera accounted for an additional two runs.