Lee's performance enabled her to end at 11-under-par 126, good for a two-stroke victory at the rain-damaged Ocean Club Golf Course at Atlantis Resort.
Tournament officials truncated the course to 12 holes after it was drenched with a foot of rain Tuesday, which rendered six of its holes unplayable.
The weather conditions also cut the event to three rounds.
Taking sole possession of second place at 9-under was Irene Cho, who carded a 7-under 40.
Anna Nordqvist claimed third place one shot further back with a 2-under 45.