Alcides Escobar drove in two Kansas City runs on a scratch single and a force out.
Jimmy Paredes gave Houston a 3-0 lead with a three-run homer in the fourth inning; however the Royals roared back with a pair of runs in the seventh, four more in the eighth and an insurance run in the ninth.
Paul Clemens (1-2) took the loss in relief of Bud Norris, who pitched six scoreless innings for the Astros. Houston had won three of their last five games prior to Tuesday.
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