With the game tied 2-2 in the 11th, Castro led off with a double against Bryan Morris (1-2). One out later, Carlos Pena was intentionally walked and both runners moved up a base on a wild pitch.
Pinch-hitter J.D. Martinez then added an insurance run with an RBI single.
Jose Cisnero (1-0) notched his first major league win with 3 2/3 shutout innings and Jose Veras collected his sixth save as the Astros evened their three-game set.
Bucs starter A.J. Burnett limited Houston to one run on five hits over seven full frames.
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