Beltran's tally included a three-run homer in the fifth to stake the Cards to a 9-0 lead and nail down their 11th win in their last 13 games.
The 11-hit outburst paved the way for John Gast (1-0) to win his Major League debut. Gast gave up four runs on six hits and struck out three.
Dillon McGee (2-5) suffered the loss after allowing six runs -- five earned -- over four innings.
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