Paul George scored 18 points to go with 14 rebounds, and Roy Hibbert hauled down 11 boards and blocked three shots as Indiana dominated the glass 54-36 margin while grabbing a commanding lead in their Eastern Conference semifinal series.
David West also had a double-double (10 points, 10 boards) and Lance Stephenson helped out with 13 points for the Pacers, who remained unbeaten at home in the post-season.
New York's Carmelo Anthony netted 24 points on 9-of-23 shooting from the floor but was held without basket in the fourth quarter for the second straight game.
J.R. Smith was held to 19 points for the Knicks, who hit only 8-of-28 three-point tries.
Indiana will attempt to close out the series Thursday at Madison Square Garden.