Beltre's blast highlighted a six-run inning that broke open a 4-4 game and propelled the Rangers to a victory in the opener of a three-game home series.
Yu Darvish (5-1) got the win despite allowing four runs on seven hits over six innings. The right-hander yielded three walks while striking out nine.
Chicago's Matt Lindstrom (1-2) was saddled with the loss in relief of starter Jose Quintana, who was touched for four runs on eight hits over five full frames.
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