Beltre's blast highlighted a six-run inning that broke open a 4-4 game and propelled the Rangers to a victory in the opener of a three-game home series.
Yu Darvish (5-1) got the win despite allowing four runs on seven hits over six innings. The right-hander yielded three walks while striking out nine.
Chicago's Matt Lindstrom (1-2) was saddled with the loss in relief of starter Jose Quintana, who was touched for four runs on eight hits over five full frames.
Putin thinks Obama would save him if he were drowning
Rosie O'Donnell unveils nearly 50-pound weight loss