Slava Voynov, Kyle Clifford and Justin Williams each netted a goal as the defending NHL champions concluded their regular season with a 27-16-5 record.
They will begin the Stanley Cup playoffs on the road against the fourth-seeded St. Louis Blues.
Antti Niemi turned aside 24 shots for sixth-seeded San Jose, which closed out the season with a 25-16-7 mark and will travel to Vancouver to start the first round.
Logan Couture and T.J. Galiardi each scored in the Sharks' regular season-ending loss.
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