Omar Infante went 2-for-3 with a solo home run for the Tigers, who outscored the Braves 25-7 in the series.
Doug Fister (4-0) overcame cold, rainy conditions in Detroit to notch his fourth win in five starts to begin the season. The right-hander struck out eight and allowed three runs on six hits without issuing a walk.
Atlanta starter Mike Minor (3-2) was tagged for six runs on six hits over 6 2/3 innings.
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