Trumbo and Conger each drove in two runs, Albert Pujols drove in a pair and Peter Bourjos had two hits and scored twice for the Angels.
C.J. Wilson (2-0) started and went 5 1/3 innings for LA, giving up three runs on seven hits with two walks and nine strikeouts.
Kelly Shoppach had two hits and drove in a run for Seattle.
The Angels got to Mariner's starter Aaron Harang (0-3) early, with a run in the first, two in the second -- when Conger hit a two-run home run -- and two more in the third, when Trumbo hit a two-run shot.
Harang went three innings, allowing five runs on six hits with two walks and one strikeout.