Phil Kessel scored twice and Toronto wrapped up no worse than the No. 5 position in the Eastern Conference standings.
Florida is headed for the worst point total in the lockout-shortened NHL season. The Panthers lost for the seventh time in eight games.
Leo Komarov and Clarke MacArthur scored in the first period and Kessel tallied twice in a span of 3 minutes during the middle stanza.
All four goals came against Jacob Markstrom on 17 shots.