The New York bullpen allowed one hit over the final three innings to nail down the victory, with Mariano Rivera picking up his seventh save.
Wells hit a solo homer in the second, Cano delivered a three-run shot in the third and Cervelli contributed a solo blast in the fourth.
All of that brought the Yankees back from a 3-0 deficit and allowed Hiroki Kuroda to claim the victory.
A two-run homer by Edwin Encarnacion in the first and a solo shot by Brett Lowrie in the second accounted for Toronto's scoring.
Mark Buehrle (1-1) took the loss, surrendering all three of the homers in 5 1/3 innings.