Tony Parker contributed 18 points, eight assists and three steals while Manu Ginobili shook off a strained hamstring to add another 18 points off the bench as the second-seeded Spurs jumped off to an early lead in their first-round Western Conference series.
The Lakers, meanwhile, fell without injured superstar Kobe Bryant, who was lost for the playoffs with a ruptured Achilles tendon late in the regular season.
Steve Nash returned from an injury provide 16 points for the Lakers.
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