Colon (2-0) allowed just four hits and struck out three while not issuing a walk en route to his second win in three starts to begin the season.
The A's gave him a big early lead, scoring six times in first inning in an outburst highlighted by Josh Reddick's two-run double.
Astros starter Bud Norris (2-2) managed to record only two outs before exiting. He was rocked for six runs on five hits while walking three in the first.
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