Evan Fournier chipped in 24 points as the Nuggets strengthened their hold on the Western Conference's third seed with a sixth win in seven games.
Denver, which held a 20-point lead in the first half, outscored the Trail Blazers 14-8 down the stretch to wrap up the victory after Portland had narrowed the deficit to three points with 3 1/2 minutes remaining.
Damian Lillard provided 30 points and six assists but committed eight turnovers as Portland fell for an 11th straight time.
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