The Blue Jays halted Kansas City's four-game winning streak, producing five runs over the first five innings and then opening a comfortable lead with a three-run sixth.
J.A. Happ (2-0) picked up the victory despite giving up four runs and three walks in five innings. Aaron Loup collected the first save of his career by working three perfect innings.
The loss went to Luis Mendoza (0-1), who surrendered eight runs in 5 2/3.
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