Columbus began the night as one of three teams within three points of Detroit for the final post-season spot in the Western Conference and the Blue Jackets came through with a key victory against a team that had won its previous six games.
St. Louis took the lead just 1:26 into the game on a slap shot from Kevin Shattenkirk and that was the only goal the Blues managed against Sergei Bobrovsky.
Cam Atkinson tied it with 5:28 left in the opening period and Anisimov scored on a tip-in with 5:40 left in the middle stanza to give the Blue Jackets the lead.
Ryan Johansen added a second-period goal and Marian Gaborik provided some insurance 1:29 into the third.
Bobrovski made 28 saves while Jake Allen, making the 14th appearance of his rookie season with the Blues, allowed all four goals on 18 shots.
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'
Exploding whale video goes viral on Internet