Detroit fell behind by seven points after one period, but dominated from then on while winning its third in a row.
Jerebko scored 21 points and grabbed eight rebounds off the bench. Brandon Knight added 19 points and Andre Drummond had 15 for the Pistons, who went 12-of-18 from beyond the 3-point arc.
The Bobcats, likely headed for the worst record in the NBA this season, lost for the fourth straight time. They have won just 18 games during the entire campaign.
Kemba Walker led Charlotte with 28 points.