The Nets built a 19-point halftime lead and held on to win their fourth straight game. Brooklyn has wrapped up no worse than a fourth-place finish in the Eastern Conference race, ensuring the Nets will have home-court advantage in the opening round of the playoffs.
Williams scored 33 points to go with 14 assists while both Johnson and Lopez produced 24 points. The rest of the team had just 36.
Brooklyn hit 51 percent of its shots from the field and made 12-of-24 from 3-point range.
Indiana, which became a runaway division champion this year and which will also open the playoffs at home, was led by David West with 26 points.