The Avalanche, owners of the worst record in the NHL, ended a five-game losing streak by defeating a team battling for the No. 1 seed in the Western Conference.
John Mitchell scored for Colorado 64 seconds into the game and the Avalanche took control with a three-goal second period.
Teemu Selanne produced Anaheim's only goal on a tip-in with 8:44 to go in the second period.
The Ducks, who had won their previous two games, remained five points behind Chicago for the best record in the West.
Turkey considering to use pistachios to heat country’s first eco-city
Moore to attend retreat in to avoid Kutcher's wedding