The Avalanche, owners of the worst record in the NHL, ended a five-game losing streak by defeating a team battling for the No. 1 seed in the Western Conference.
John Mitchell scored for Colorado 64 seconds into the game and the Avalanche took control with a three-goal second period.
Teemu Selanne produced Anaheim's only goal on a tip-in with 8:44 to go in the second period.
The Ducks, who had won their previous two games, remained five points behind Chicago for the best record in the West.
Notable deaths of 2014 [PHOTOS]
UPI Sports Results for September 19, 2014