Kemba Walker led Charlotte with 19 points. The Bobcats have lost their last 13 road contests.
Charlotte struggled with a 37.5 percent mark from the floor. Memphis shot 47.6 percent and led 49-30 at halftime.
Both sides struggled from beyond the arc, as the two teams combined to make 5- of-27 shots from 3-point range. Memphis enjoyed a 50-34 edge in points in the paint.