Coco Crisp supplied a bases-empty clout as the Athletics reeled off their fifth straight after going 0-2 to start the season.
Brett Anderson (1-1) garnered the victory, allowing just two unearned runs on five hits over six innings. He issued two walks and struck out 10.
The Astros' Lucas Harrell (0-2) was tagged with the loss, surrendering eight runs on seven hits with five walks over 4 1/3 frames.
Carlos Corporan drove in a run for Houston, which dropped a fifth consecutive game.
Notable deaths of 2014 [PHOTOS]